百人牛牛游戏

百人牛牛游戏:许强华 教授

发布时间:2024-03-07

浏览次数:12440

1.个人基本情况:

许强华,女,博士,教授,博士生导师,上海市“曙光学者”、上海市“浦江学者”,上海市“青年科技启明星”,上:Q蟠笱ШQ笱д,上:Q蟠笱捉旌E秆д。四川大学生命科学百人牛牛游戏动物学专业理学学士;西北大学生命科学百人牛牛游戏动物学专业理学硕士(动物遗传方向);浙江大学生命科学百人牛牛游戏动物学专业理学博士(保护遗传与分子生态学方向);日本九州大学生命科学学府访问学者(一年);美国密歇根州立大学渔业与野生动物学系访问学者(两年)。以研究海洋动物环境适应与分子进化机制为核心内容,聚焦南极、深渊和高原水域,开展极端环境生物适应进化机制与基因资源挖掘研究工作,解析水生物种响应低温、低氧环境胁迫的调控网络与适应性进化。先后主持科技部重点研发计划课题1项,主持国家自然科学基金项目5项、主持教育部科学技术研究项目1项、主持上海市教委曙光项目、上海市科委浦江人才计划等各级课题10余项,骨干参加国家科技部重点研发计划3项、国家基金委国际合作项目、国家基金委重点项目、国家海洋863等多个重大项目。以第一/通讯作者(含共同)BMC Biology, Molecular Ecology Resource, Molecular Ecology, Gigascience, Molecular Biology & Evolution等国际知名杂志上发表SCI收录论文40余篇,SCI引用检索他引次数达700余次。研究成果获2019年度海洋科学技术奖一等奖(排名第2,2/15)、2020年教育部高等百人牛牛游戏科学研究优秀成果奖一等奖(排名第2,2/12)。

 

2.主要研究方向:

实验室主要研究方向是极端环境生物适应进化机制与基因资源挖掘,特别关注南极极端低温、青藏高原低氧、以及深渊极端环境条件下,动物的适应性分子发育及进化机制。目前实验室的研究方向包括:

[1]南极鱼类适应极端低温环境下的心血管发育与进化机制;

[2]青藏高原裂腹鱼高原适应的分子进化机制;

[3]深渊宏生物的适应性进化机制;

[4]鱼类的低温/低氧胁迫适应与分子进化机制;

[5]鱼类抗逆基因的挖掘和利用。

 

3.承担的代表性科研项目:

[1]国家自然科学基金面上项目、两种极端环境海洋鱼类心脏发育的分子进化机制比较研究、2025-2028、项目负责人。

[2]国家科技部重点研发计划项目、草鱼养殖新发疫病的发生流行规律与防控技术研发与示范、2024-2028、子课题负责人。

[3]国家科技部重点研发计划项目、耐高温大口黑鲈和抗链球菌病罗非鱼新品种培育、2022-2026、子课题负责人。

[4]国家科技部重点研发计划项目、重要养殖生物应对温度胁迫的生理和发育响应机制与生态效应研究、2018-2022、子课题负责人。

[5]国家科技部重点研发计划项目、深渊宏生物生命过程前沿科学研究、2018-2021、课题负责人。

[6]国家自然科学基金面上项目、青藏高原裂腹鱼血细胞的分子发育与适应机制研究、2018-2021、项目负责人。

[7]国家自然科学基金面上项目、南极冰鱼血红细胞丢失的表观遗传调控与低氧适应机制研究、2016-2019、项目负责人。

[8]国家自然基金委国际(地区)合作与交流项目、鱼类免疫在极端环境下的进化、2017-2019、骨干参加人员。

[9]上海市浦江人才计划项目、南极冰鱼心脏增大相关microRNA的筛选与功能鉴定、2016-2018、项目负责人。

[10]国家教育部科学技术研究项目、青藏高原裂腹鱼类遗传种质资源开发及应用研究、2013-2016、项目负责人。

[11]上海市教委曙光人才计划项目、南极冰鱼血红细胞丢失的分子进化机制研究、2013-2016、项目负责人。

[12]国家基金委重点项目、青藏高原裂腹鱼类的分子进化和高原适应的机制研究、2012-2016、骨干参加人员。

[13]国家自然科学基金重大研究计划培育项目、南极冰鱼心血管发育和功能适应的分子进化研究、2012-2014、项目负责人。

[14]国家自然科学基金青年科学基金项目、三疣梭子蟹盐度适应相关重要基因的克隆及其调控研究、2009-2011、项目负责人。

[15]国家海洋863重点项目、海洋文昌鱼的人工繁育与养殖及其生殖相关功能基因的研究、2009-2012、子项目负责人。

[16]上海市科委青年科技启明星人才计划项目、2009-2011、项目负责人。

 

4.代表性SCI 论文(*通讯作者):

[1] Qianghua Xu*, Ruonan Jia, Fei Yang, Peng Hu, Xue Li, Saiya Ge, Shouwen Jiang, Jiulin Chan, Wanying Zhai, Liangbiao Chen*(2024). Identification of two miRNAs regulating cardiomyocyte proliferation in an Antarctic icefish. iScience 27, 110128, June 21, 2024. (共同通讯)

[2] Wenhao Li#, Jie Song#, Huaming Tu#, Shouwen Jiang#, Binbin Pan, Jiazhen Li, Yongpeng Zhao, Liangbiao Chen*, Qianghua Xu* (2024). Genome sequencing of Coryphaenoides yaquinae reveals convergent and lineage-specific molecular evolution in deep-sea adaptation. Molecular Ecology Resources, 2024; 00: e13989. (共同通讯)

[3] Lei Chen, Shouwen Jiang, Binbin Pan, Qianghua Xu* (2024). Development of Single-Nucleotide Polymorphism Markers and Population Genetic Analysis of the Hadal Amphipod Alicella gigantea across the Mariana and New Britain Trenches. Journal of Marine Science and Engineering. 2024, 12, 1117.(通讯作者)

[4] Songqian Huang, Chenyu Yan, Yuan Xu, He Jiao, Minghao Zhang, Jiangbo Cheng, Wenting Wang, Zongbin Cui, Liangbiao Chen, Peng Hu*, Qianghua Xu*. Integrated transcriptomic and epigenomic analyses to disclose the transcriptional regulatory mechanisms of lipid and energy metabolism under cold stress in grass carp. Aquaculture 595 (2025) 741526. (共同通讯).

[5] Shaojun Huang, Lingyue Zhu, Shouwen Jiang, Wanying Zhai, Binbin Pan, Zhichao Wu, Qianghua Xu* (2023). Metal Accumulations in Two Extreme-Environment Amphipods, Hadal Eurythenes gryllus and Antarctic Pseudorchomene plebs. Journal of marine science and engineering, 2023, 11(8), 1515. (通讯作者)

[6] Ying Lu#, Wenhao Li#, Yalin Li#, Wanying Zhai#, Xuming Zhou#, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu*, Adelino V. M. Canário* and Liangbiao Chen* (2022). Population genomics of an icefsh reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids. BMC Biology, 20: 231. https://doi.org/10.1186/s12915-022-01432-x. (共同通讯)

[7] Wenhao Li, Faxiang Wang, Shouwen Jiang, Binbin Pan, Qi Liu, Qianghua Xu*(2022). Morphological and molecular evolution of hadal amphipod’s eggs provides insights into embryogenesis under high hydrostatic pressure. Frontiers in Cell and Developmental Biology, 2022, 10:987409. doi: 10.3389/fcell.2022.987409. (通讯作者)

[8] Jiulin Chan, Daoqiang Geng, Binbin Pan, Qiming Zhang, Qianghua Xu* (2022). Gut microbial divergence between three hadal amphipod species from the isolated hadal trenches. Microbial Ecology, 84:627–637. https: //doi.org/ 10.1007/ s00248-021-01851-3. (通讯作者)

[9] Ruonan Jia#, Shaojun Huang#, Wanying Zhai#, Shouwen Jiang, Wenhao Li, Faxiang Wang, Qianghua Xu* (2022). Comparative proteomic analysis of head kidney among three Antarctic fshes. Marine Biology, 2022, 169:58. https://doi.org/10.1007/s00227-022-04043-w. (通讯作者)

[10] Linghui Shi, Lei Chen, Shouwen Jiang, Zhichao Wu, Yan Zhou, Qianghua Xu* (2022). Hematogenesis Adaptation to Long-Term Hypoxia Acclimation in Zebrafish (Danio rerio). Fishes, 2022, 7, 98. https://doi.org/10.3390/fishes7030098. (通讯作者)

[11] Qi Liu, Shouwen Jiang, Wenhao Li, Binbin Pan, Qianghua Xu*(2022). Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods. Journal of Marine Science and Engineering, 2022, 10,454. (通讯作者)

[12] Lingyue Zhu, Daoqiang Geng, Binbin Pan, Wenhao Li, Shouwen Jiang, Qianghua Xu* (2022). Trace elemental analysis of the exoskeleton, leg muscle and gut of three hadal amphipods. Biological Trace Element Research, 200, 1395–1407.(通讯作者)

[13] Zhicong Zhang, Fengyu Ji, Shouwen Jiang, Zhichao Wu, Qianghua Xu* (2022). Scale Development-Related Genes Identified by Transcriptome Analysis. Fishes, 2022, 7, 64. (通讯作者)

[14] Congcong Wang#*, Qin Zhang#, Yang Liu, Qianghua Xu* (2022). Characterization of EPO H131S as a key mutation site in the hypoxia adaptive evolution of Gymnocypris dobula. Fish Physiol Biochem. https://doi.org/10.1007/s10695-022-01080-6 (共同通讯).

[15] Wenhao Li#, Faxiang Wang#, Shouwen Jiang, Binbin Pan, Jiulin Chan, Qianghua Xu* (2021). The Adaptive Evolution and Gigantism Mechanisms of the Hadal “Supergiant” Amphipod Alicella gigantea. Frontiers in Marine Science, 2021,8:743663 (通讯作者)

[16] Jiulin Chan, Daoqiang Geng, Binbin Pan, Qiming Zhang, Qianghua Xu* (2021). Metagenomic insights into the structure and function of intestinal microbiota of the hadal amphipods. Frontiers in Microbiology, 2021, 668989. (通讯作者)

[17] Shaojun Huang#, Ruonan Jia#, Ruiqin Hu, Wanying Zhai, Shouwen Jiang, Wenhao Li, Faxiang Wang, Qianghua Xu*(2021). Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps. Journal of Fish Biololy, 2021;99:1998–2007. (通讯作者)

[18] Jiulin Chan, Binbin Pan, Daoqiang Geng, Qiming Zhang, Shun Zhang, Jian Guo, Qianghua Xu* (2020). Genetic diversity and population structure analysis of three deep-sea amphipod species from geographically isolated hadal trenches in the Pacific Ocean. Biochemical Genetics, 58:157-170. (通讯作者)

[19] Congcong Wang#, Xiaohui Wu#, Xingxing Hu, Huapeng Jiang, Liangbiao Chen*, Qianghua Xu* (2020). Hypoxia-inducible factor 1α from a high-altitude fish enhances cytoprotection and elevates Nitric Oxide production in hypoxic environment. Fish Physiol Biochem, 46:39-49.(共同通讯)

[20] Shaojun Huang, Shan Jiang, Qianghua Xu* (2020). Acute salinity stress in Gill Na+/K+-ATPase in the swimming crab, Portunus trituberculatus (Brachyura, portunidae). Crustaceana, 93(6): 587-609.(通讯作者)

[21] Liangbiao Chen#, Ying Lu#, Wenhao Li#, Yandong Ren, Mengchao Yu, Shouwen Jiang, Yanxia Fu, Jian Wang, Sihua Peng, Kevin T. Bilyk, Katherine R. Murphy, Xuan Zhuang, Mathias Hune; Wanying Zhai, Wen Wang, Qianghua Xu*, Chi-Hing Christina Cheng*. (2019) Genomic bases for colonizing the freezing Southern Ocean revealed by the genomes of Antarctic toothfish and Patagonia robalo. GigaScience. (共同通讯)

[22] Jiulin Chan, Xingxing Hu, Congcong Wang, Qianghua Xu*(2018). MiRNA-152 targets GATA1 to regulate erythropoiesis in Chionodraco hamatus. Biochemical and Biophysical Research Communications 501: 711-717 (通讯作者)

[23] Dongsheng Zhang#, Mengchao Yu#,, Peng Hu, Sihua Peng, Yimeng Liu, Weiwen Li, Congcong Wang, Shunping He, Wanying Zhai, Qianghua Xu*, and Liangbiao Chen*(2017). Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai–Tibetan Plateau. G3: Genets Genomics Genetics, 7:1207-1275 (共同通讯)

[24] Mengchao Yu#, Dongsheng Zhang#, Peng Hu, Sihua Peng, Weiwen Li, Shunping He, Wanying Zhai, Qianghua Xu*, Liangbiao Chen* (2017). Divergent adaptation to Qinghai-Tibetan Plateau implicated from transciptome study of Gymnocypris dobula and Schizothorax nukiangensis. Biochemical Systematics and Ecology, 71:97-105 (共同通讯)

[25] Lixue Cao#, Qiao Huang#, Zhichao Wu#, Dongdong Cao#, Zhanling Ma#, Qianghua Xu, Peng Hu, Yanxia Fu, Yu Shen, Jiulin Chan, Congzhao Zhou, Wanying Zhai, and Liangbiao Chen* (2016) Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids. Nature Communication, 7:12987(参加作者)

[26] Qianghua Xu*, Chi Zhang, Dongsheng Zhang, Huapeng Jiang, Sihua Peng, Yang Liu, Kai Zhao, Congcong Wang and Liangbiao Chen*.(2016). Analysis of the erythropoietin of a Tibetan Plateau schizothoracine fish (Gymnocypris dobula) reveals enhanced cytoprotection function in hypoxic environments. BMC Evolutionary Biology 16 (1): 11(共同通讯)

[27] Jiulin Chan, Weiwen Li, Xingxing Hu, Yimeng Liu, Qianghua Xu* (2016). Genetic diversity and population structure analysis of Qinghai-Tibetan plateau schizothoracine fish (Gymnocypris dobula) based on mtDNA D-loop sequences. Biochemical Systematics and Ecology, 69: 152-160(通讯作者)

[28] Shaojun Huang, Qianghua Xu*(2016). Ferritin Gene from the Swimming Crab (Portunus trituberculatus) Involved in Salinity Stress Adaptation. Turkish Journal of Fisheries and Aquatic Sicences, 2016, 16(1): 141-153(通讯作者)

[29] Weiwen Li, Yang Liu, Qianghua Xu* (2016). The complete mitochondrial genome of Schizothorax yunnanensis paoshanensis (Cyprinidae: Schizothorax). Mitochondrial DNA Part A, 27(4): 2504-2505 (通讯作者)

[30] Weiwen Li, Yang Liu, Qianghua Xu* (2016). Complete mitochondrial genome of Schizothorax nukiangensis Tsao (Cyprinidae: Schizothorax) . Mitochondrial DNA Part A, 27(5): 3549-3550 (通讯作者)

[31] Qianghua Xu*, Chang Cai, Xingxing Hu, Yun Liu, Yanan Guo, Peng Hu, Zuozhou Chen, Sihua Peng, Dongsheng Zhang, Shouwen Jiang, Zhichao Wu, Jiulin Chan and Liangbiao Chen* (2015). Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish. Molecular Ecology, 24: 4664–4678 (共同通讯)

[32] WeiwenLi, Xinjun Chen, Qianghua Xu*, Jiangfeng Zhu, Xiaojie Dai, Liuxiong Xu (2015). Genetic population structure of the Thunnus albacares in the central Pacific Ocean based on mtDNA COI gene sequences. Biochemical Genetics, 53:8–22 (通讯作者)

[33] Shaojun Huang, Qianghua Xu* (2015). Molecular cloning of the Calcyclin Binding Protein gene from Portunus trituberculatus and its roles in salinity stress adaptation. Journal of Shellfish Research 34(3):1057–1064 (通讯作者)

[34] Zhichao Wu, Qianghua Xu*, Jiangfeng Zhu, Xiaojie Dai, Liuxiong Xu (2014). Genetic population structure of the bigeye tuna Thunnus obesus in the central Pacific Ocean based on mtDNA Cytb sequences. Fishery Science, 80:415–426 (通讯作者)

[35] Qianghua Xu#, Guang Li#, Lixue Cao#, Zhongjun Wang, Hua Ye, Xiaoyin Chen, Xi Yang, Yiquan Wang, Liangbiao Chen* (2012). Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri. BMC evolutionary biology, 12:239(共一作者)

[36] Qianghua Xu*, Ye Qin (2012). Molecular cloning of heat shock protein 60 (PtHSP60) from Portunus trituberculatus and its expression response to salinity stress. Cell Stress and Chaperones, 17:589-601 (通讯作者)

[37] Qianghua Xu, Jun Tan, Liangbiao Chen* (2012). Characterization and evolution analyses of a Jun like gene in amphioxus Branchiostoma japonicum. Journal of Genetics and Genomics 39(11): 607-611.

[38] Qianghua Xu*, Yang Liu (2011). Gene Expression Profiles of the Swimming Crab Portunus trituberculatus Exposed to Salinity Stress. Marine Biology 158:2161-2172 (通讯作者)

[39] Qianghua Xu*, Ru Liu (2011). Development and Characterization of Microsatellite Markers for the Genetic Analysis of the Swimming Crab, Portunus trituberculatus. Biochemical Genetics 49:202-212 (通讯作者)

[40] Qianghua Xu*, Yang Liu, Ronglei Liu (2010). Expressed sequence tags from cDNA library prepared from gills of the swimming crab, Portunus trituberculatus. Journal of Experimental Marine Biology and Ecology, 394:105-115 (通讯作者)

[41] Qianghua Xu*, Ronglei Liu, Yong Liu (2009). Genetic population structure of the swimming crab, Portunus trituberculatus in the East China Sea based on mtDNA 16S rRNA sequences. Journal of Experimental Marine Biology and Ecology, 371:121-129 (通讯作者)